![]() ![]() ![]() In four meta‐analyses, two in TRS only 16, 17 and two in TRS and non‐TRS patients 18, 19, CLZ performed better than other antipsychotics except for haloperidol 17, second‐generation antipsychotics as a group 17, risperidone 19, and zotepine 19. Three randomized controlled trials in TRS patients point to better efficacy for CLZ 13, 14, 15, as well as better treatment adherence 14, 15, relative to other antipsychotics except for olanzapine 15. In two observational studies, one in TRS and non‐TRS patients 11 and the other in TRS patients only 12, improved treatment adherence for CLZ relative to other antipsychotics was demonstrated. The ongoing debate about when to initiate CLZ could possibly explain the current underutilization.Ī number of approaches have been applied in different study designs to investigate CLZ's superiority to other antipsychotics. This delay may worsen outcome as increasing numbers of exacerbations of psychotic symptoms impair daily functioning 8, 9, 10. CLZ is prescribed late in the course of illness 6, with an estimated time lag of ≥5 years 7. CLZ is also known to be one of the most effective antipsychotic agents 1, 2, 3, 4. In most countries, clozapine (CLZ) is the only registered drug for treatment‐resistant schizophrenia (TRS). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |